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January 23, 2026Journal of Crohn s and Colitis

P0397Soluble Transferrin Receptor as a Reliable Inflammation-Independent Marker of Iron Deficiency in Crohn’s Disease and Ulcerative Colitis

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Authors

FPFernando Victor Monteiro PortelaMSM P Ministro dos SantosHSH Tavares de Sousa

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Overview

Cross-sectional study assesses soluble transferrin receptor in identifying iron deficiency in inflammatory bowel disease, suggesting its reliability.

Key Points

  • This study examines the effectiveness of soluble transferrin receptor (sTfR) as an inflammation-independent marker of iron deficiency in IBD.
  • Conducted a multicentre, cross-sectional study involving IBD patients and controls.
  • Classified iron status using two definitions: conventional and stricter involving transferrin saturation.
  • Compared sTfR levels across different patient groups and employed ROC curve analysis to determine diagnostic cut-offs.
  • Among UC patients, sTfR levels were significantly higher in those with IDWA compared to non-IDWA patients (1.20 mg/L vs 1.05 mg/L, p=0.013).
  • Anaemic UC patients exhibited elevated sTfR levels compared to non-IDWA individuals (1.27 mg/L vs non-IDWA, p<0.001).
  • In CD, no significant differences in sTfR levels between IDWA and non-IDWA patients, but anaemic patients had higher levels (p=0.003).

Cite This Study

Portela et al. (2026) studied this question.

synapsesocial.com/papers/69731005c8125b09b0d1fc1ehttps://doi.org/10.1093/ecco-jcc/jjaf231.578
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Soluble transferrin receptor as a reliable inflammation-independent marker of iron deficiency in Crohn’s disease and ulcerative colitis2026 · 1 citations
  2. 2P0463 Distinct Hepcidin Dynamics in Crohn’s Disease and Ulcerative Colitis: Links to Iron Homeostasis and Inflammatory Activity2026
  3. 3P0689 High-dose IV iron safely and effectively treats IBD-associated anaemia regardless of inflammatory activity – real-life evidence from Germany2026
  4. 4P0910 Dietary Micronutrient Gaps in IBD: Differences Between Active Disease and Remission2026 · 1 citations
  5. 5The Role of Hepcidin, sTfR, and sTfR/Log Ferritin Index for the Differential Diagnosis of Iron Deficiency Anemia and Anemia of Chronic Disease2024 · 1 citations