DOP028Treat-to-target optimization is effective on endoscopic and histologic outcomes in a real-life cohort of ulcerative colitis – the TACTIC-UC Study
Retrospective study shows treat-to-target strategies improve endoscopic and histologic outcomes in UC patients, indicating effective management pathways.
Key Points
The study aims to evaluate the effectiveness of endoscopy-guided optimization of biologic therapy in achieving deeper healing in ulcerative colitis patients with minimal symptoms.
Conducted a single-center, retrospective evaluation of ulcerative colitis patients.
Included patients with mild symptoms but severe endoscopic activity.
Assessed mucosal healing and remission rates within one year post-optimization.
54.2% achieved mucosal healing within one year.
28.8% reached endoscopic remission, while 20.9% achieved histo-endoscopic mucosal remission.
Anti-TNF therapies showed significantly better outcomes compared to other biologics.