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January 23, 2026Journal of Crohn s and Colitis

P0514Clinical characteristics of twins with Inflammatory Bowel Disease: 7-year follow-up

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Authors

SDS DijkstraEBE BrandFWF van Wijk

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Overview

Longitudinal analysis reveals concordance patterns of IBD in twins, suggesting genetic influences on disease onset.

Key Points

  • The study aims to investigate the clinical characteristics and genetic factors influencing Inflammatory Bowel Disease in twins.
  • Recruited twin pairs with Inflammatory Bowel Disease through clinical referrals and online promotion.
  • Collect baseline data via questionnaires covering disease characteristics, medication use, and quality of life.
  • Medical records were analyzed to confirm diagnoses and disease classification.
  • Biological samples were collected from twins every six months for two years, regardless of disease status.
  • Conducted follow-up assessments in October 2025 to update current disease status.
  • 64 twin pairs with at least one IBD member were recruited, including 34 monozygotic and 30 dizygotic pairs.
  • Concordance for Crohn's disease was found in 9 monozygotic pairs; no dizygotic pairs were concordant for UC.
  • 60% of concordant CD twins shared the same disease classification attributes at baseline.
  • During follow-up, two previously unaffected twins were later diagnosed with IBD, confirming concordance.
  • Median time between diagnoses in concordant pairs was 2 years, with a range of 0 to 18 years.

Cite This Study

Dijkstra et al. (2026) studied this question.

synapsesocial.com/papers/69731022c8125b09b0d1fd76https://doi.org/10.1093/ecco-jcc/jjaf231.695
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