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This study aims to investigate how mucosal healing and intensified treatment strategies affect quality of life in ulcerative colitis patients.

P0734Quality of life and mucosal healing in Ulcerative Colitis: CAVI_CU prospective study by GETECCU

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This study aims to investigate how mucosal healing and intensified treatment strategies affect quality of life in ulcerative colitis patients.
Prospective, multicenter study conducted from November 2022 to November 2024.
Participants included UC patients in clinical remission with Mayo endoscopic scores 0 or 1.
Clinical outcomes were measured using C-reactive protein, fecal calprotectin, and QoL instruments at baseline, 6, and 12 months.
Logistic regression analysis was used to determine predictors of clinical relapse.
234 patients were included with diverse Mayo endoscopic subscores, showing significant differences in fecal calprotectin levels between subscores.
Mayo 1 patients had higher treatment modification and intensification rates compared to Mayo 0.
At 6 months, relapse rates were significantly higher in Mayo 1 patients, alongside worse quality of life scores.
Mayo 1 was identified as an independent risk factor for clinical relapse at both follow-up points.

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Prospective study evaluates QoL impact of treatment on UC patients with mucosal healing, indicating significant implications for therapy decisions.

Alonso et al. (2026) studied this question.

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Prospective study evaluates QoL impact of treatment on UC patients with mucosal healing, indicating significant implications for therapy decisions.