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P0448Impact of baseline vitamin D deficiency on clinical outcomes in patients with Inflammatory Bowel Disease treated with adalimumab: a propensity-matched cohort study

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A propensity-matched cohort study shows that low baseline vitamin D worsens outcomes in IBD patients, suggesting a need for optimization.

This study aimed to determine the impact of baseline vitamin D deficiency on clinical outcomes in IBD patients treated with adalimumab.
Retrospective cohort study utilizing the TriNetX U.S. Collaborative Network.
Included adult patients with Crohn’s disease or ulcerative colitis receiving adalimumab from 2018-2024.
Patients were stratified by baseline vitamin D levels: ≥20 ng/mL and <19 ng/mL.
Propensity score matching was used to balance cohorts across demographics and comorbidities.
Evaluated outcomes over 365 days, including various inflammatory and clinical markers.
Vitamin D deficiency was associated with higher risks of CRP elevation, steroid use, and inpatient encounters.
Deficient patients had increased odds of anemia and hypoalbuminemia compared to those with sufficient levels.
Survival analysis indicated reduced survival free of adverse events in the vitamin D-deficient cohort.

Johal et al. (2026) studied this question.

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View Full Paper

Ask AI

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Authors

A propensity-matched cohort study shows that low baseline vitamin D worsens outcomes in IBD patients, suggesting a need for optimization.

This study aimed to determine the impact of baseline vitamin D deficiency on clinical outcomes in IBD patients treated with adalimumab.
Retrospective cohort study utilizing the TriNetX U.S. Collaborative Network.
Included adult patients with Crohn’s disease or ulcerative colitis receiving adalimumab from 2018-2024.
Patients were stratified by baseline vitamin D levels: ≥20 ng/mL and <19 ng/mL.
Propensity score matching was used to balance cohorts across demographics and comorbidities.
Evaluated outcomes over 365 days, including various inflammatory and clinical markers.
Vitamin D deficiency was associated with higher risks of CRP elevation, steroid use, and inpatient encounters.
Deficient patients had increased odds of anemia and hypoalbuminemia compared to those with sufficient levels.
Survival analysis indicated reduced survival free of adverse events in the vitamin D-deficient cohort.

Johal et al. (2026) studied this question.

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