Enantioselective C(sp³)–H Bond Functionalization Enabled by Cp x M(III) Catalysis (M = Co, Rh, Ir)

Shu-Bin Mou; Mu-Peng Luo; Feifei Fang; Shi Cao; Dong Xia Wu; Shouguo Wang

doi:10.1039/d5sc08394j

January 1, 2026Chemical ScienceOpen Access

Enantioselective C(sp³)–H Bond Functionalization Enabled by Cp x M(III) Catalysis (M = Co, Rh, Ir)

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Key Points

The study aims to explore the use of Group 9 transition metals in asymmetric C(sp³)–H bond functionalization.
Utilized Cp x M(III) catalysis (M = Co, Rh, Ir) for C(sp³)–H bond functionalization.
Examined various pentamethylcyclopentadienyl ligands in the process.
Analyzed the enantioselectivity of the reactions involved.
Achieved significant enantioselectivity in the functionalization process.
Demonstrated the versatility of different metal catalysts (Co, Rh, Ir).
Confirmed that tailored ligands enhance the effectiveness of the reactions.

Abstract

Trivalent Group 9 transition metals (Co, Rh, and Ir) bearing pentamethylcyclopentadienyl (Cpx) or structurally tailored Cpx ligands have emerged as a transformative platform for asymmetric C(sp³)–H functionalization. Despite significant progress...

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Cite This Study

Mou et al. (2026) studied this question.

synapsesocial.com/papers/6973106cc8125b09b0d20261 https://doi.org/10.1039/d5sc08394j

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Enantioselective C(sp³)–H Bond Functionalization Enabled by Cp x M(III) Catalysis (M = Co, Rh, Ir)

Key Points

Abstract

Discussion

Cite This Study

Enantioselective C(sp³)–H Bond Functionalization Enabled by Cp x M(III) Catalysis (M = Co, Rh, Ir)

Key Points

Abstract

Discussion

Cite This Study

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