P0456Higher prevalence and psychosocial burden of IBS in IBD patients: A Rome IV–based comparative analysis

Background Irritable bowel syndrome (IBS) symptoms frequently overlap with inflammatory bowel disease (IBD), but the prevalence of IBS defined by the strict Rome IV criteria in Korean IBD and its impact on patient quality of life (QoL) remain unclear. We aimed to calculate the prevalence of Rome IV–defined IBS in IBD patients in clinical remission and to evaluate differences in QoL and psychosocial measures between IBD patients with and without IBS. Methods We conducted a cross-sectional study of 215 adult IBD patients (76 Crohn’s disease [CD], 139 ulcerative colitis [UC]) in clinical remission at two tertiary centres. IBS was defined using Rome IV criteria via a validated symptom questionnaire. QoL was assessed using the 36item Short Form survey (SF36), perceived stress by the Brief Encounter Psychosocial Instrument (BEPSIK), and anxiety/depression by the Hospital Anxiety and Depression Scale (HADS). Comparisons between IBS and nonIBS groups within CD and UC were performed using independent t tests, Mann–Whitney U tests, or Fisher’s exact tests, as appropriate. Results IBS was identified in 16 (7.4%) of 215 IBD patients. IBS prevalence was higher in CD (10.5%) than in UC (5.8%). IBD patients with concurrent IBS had markedly reduced QoL, with median total SF36 scores of 68.4 versus 79.2 in nonIBS patients (p = 0.002). In the CD subgroup, IBSpositive patients showed significantly lower median total SF36 scores (66 vs 80; p = 0.008) and worse SF36 domain scores for vitality, pain, general health, and social functioning (all p < 0.05) compared with CD patients without IBS. In UC, IBS patients had lower total SF36 (66 vs 80), vitality (44 vs 55), and pain (58 vs 90) domain scores (all p < 0.05), whereas social functioning and general health did not differ significantly. IBS patients also tended to report higher stress (BEPSIK) and HADS anxiety/depression scores, reflecting greater psychosocial burden, although these differences were not statistically significant. Conclusion IBS occurs frequently in Korean IBD patients in clinical remission, even under the strict Rome IV criteria, and is associated with significantly impaired QoL. The impact of IBS on quality of life in CD appears more severe than in UC, suggesting a greater psychosocial and systemic burden in Crohn’s disease. Conflict of interest: Kim, Dong Woo: No conflict of interest Jang, Jinook: No conflict of interest Park, Su Bum: No conflict of interest Lee, Hong Sub: No conflict of interest