This review summarizes recent developments in carbon-to-nitrogen and nitrogen-to-carbon transmutations in aromatic systems, indicating promising advances in organic synthesis.
Key Points
The aim is to explore advancements in single-atom skeletal editing of aromatic compounds, focusing on carbon-to-nitrogen and nitrogen-to-carbon transformations.
Overview of recent innovations in C-to-N and N-to-C transmutation techniques.
Discussion of oxidative ring expansion, electrophilic rearrangement, and ring-opening strategies.
Review of synthetic applications in medicinal chemistry, particularly for drug design.
C-to-N transformations successfully convert quinolines into quinazolines, which are important for pharmaceuticals.
N-to-C editing techniques allow the transformation of nitrogen-containing heterocycles into substituted benzenes.
These methodologies enhance drug design, late-stage functionalization, and diversification of heterocycles.