P0854Role of GLIM criteria in diagnosing malnutrition among IBD outpatients: a prospective monocentric Moroccan study

Background Malnutrition is a common but under-recognized complication in Inflammatory Bowel Disease (IBD), with prevalence estimates ranging from 15–60%. The recent Global Leadership Initiative on Malnutrition (GLIM) framework offers a standardized diagnostic approach, yet its performance in North African IBD populations remains unclear. Aim To determine the prevalence of malnutrition among IBD outpatients using GLIM criteria, compare GLIM with WHO, SGA, and ESPEN definitions, and evaluate associations with disease activity, body composition, quality of life, and fatigue. Methods A prospective monocentric observational study was conducted at the IBD clinic of CHU Mohammed VI Marrakech from January to May 2024.A total of 235 IBD outpatients were enrolled (145 Crohn’s disease, 90 ulcerative colitis).All patients underwent: • nutritional risk screening (MUST), • malnutrition diagnosis using GLIM, WHO, SGA, and ESPEN criteria, • body composition evaluation by BIA, • quality of life assessment (IBDQ), • fatigue evaluation (FACIT-F). Results GLIM criteria identified 12.3% of IBD outpatients as malnourished, a higher prevalence than WHO (7%), SGA (5%), and ESPEN (10%).GLIM-positive patients were predominantly male, diagnosed at a younger age, and less frequently in clinical remission. They showed a significantly higher rate of moderate disease activity and greater corticosteroid exposure. Malnourished patients also had a lower BMI (20 vs 24.6 kg/m²), a higher prevalence of sarcopenia, and significantly reduced ASMI and FFMI on body composition analysis. GLIM-defined malnutrition was associated with lower IBDQ scores, reflecting poorer quality of life, whereas FACIT-F fatigue scores did not differ significantly between groups. Conclusion In this large Moroccan monocentric IBD cohort, GLIM criteria identified the highest proportion of malnourished patients, outperforming WHO, SGA, and ESPEN definitions. GLIM-based malnutrition strongly correlated with active disease, sarcopenia, and impaired quality of life. These findings support integrating GLIM into routine nutritional assessment in IBD outpatient care, with future multicenter validation warranted. Conflict of interest: Dr. Aouroud, Hala: No conflict of interest Aouroud, Meryem: No conflict of interest Nacir, Oussama: No conflict of interest Lairani, Fatima Ezzahra: No conflict of interest Ait Errami, Adil: No conflict of interest Oubaha, Sofia: No conflict of interest Samlani, Zouhour: No conflict of interest Krati, Khadija: No conflict of interest