Coumarin functionalized NIR fluorescent probe based on thiopyrone skeleton for the detection of Cys and its applications

Huan Zhang; Baoze Guo; Junqing Zhou; Cong Sun; Jinwei Zhang; Shuai Guo; Songhua Zhu; Youlai Zhang

doi:10.1039/d5ay02068a

January 1, 2026Analytical Methods

Coumarin functionalized NIR fluorescent probe based on thiopyrone skeleton for the detection of Cys and its applications

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Key Points

The aim is to develop a fluorescent probe for highly sensitive detection of cysteine, enhancing diagnostic methods.
Designed a coumarin functionalized probe based on thiopyrone.
Evaluated sensitivity through fluorescence signal alterations.
Utilized various assays to test the probe's performance in detecting cysteine.
Achieved significant changes in fluorescence signals in the presence of cysteine.
Demonstrated high specificity for cysteine compared to other amino acids.
Proved effective in biological samples, showing potential for clinical applications.

Implication

Research demonstrates a novel fluorescent probe for cysteine detection, suggesting improved diagnostic potential.

Abstract

Cysteine fluorescent probes are specialized molecular tools that facilitate highly sensitive detection of cysteine via alterations in fluorescent signals. Currently, these probes have been widely employed in fields including disease...

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Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/697310b0c8125b09b0d2063a https://doi.org/10.1039/d5ay02068a

View at Publisher

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Coumarin functionalized NIR fluorescent probe based on thiopyrone skeleton for the detection of Cys and its applications

Key Points

Implication

Abstract

Discussion

Cite This Study

Coumarin functionalized NIR fluorescent probe based on thiopyrone skeleton for the detection of Cys and its applications

Key Points

Implication

Abstract

Discussion

Cite This Study

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