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January 24, 20261 citationsOpen Access

Combined polyphenols in Psidium guajava-citrus limon leaf extract attenuate fructose-induced cardiac injury by modulating metabolic and oxidative stress pathways in rats.

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HEHend A. EssaDEDina E. ElMosbahHFHeba A. Fahmy

Key Points

  • The aim is to investigate the effects of combined polyphenols from guava and lemon leaves on fructose-induced cardiac injury in rats.
  • Administered extract of Psidium guajava and citrus limon leaves to rats.
  • Induced cardiac stress using fructose.
  • Measured biomarkers for oxidative stress and cardiac injury.
  • Significant reduction in markers of cardiac injury in treated rats.
  • Improved metabolic function observed in the experimental group.
  • Reduced oxidative stress levels compared to fructose-only group.

Abstract

The combined lemon-guava leaf extract alleviates fructose-induced cardiac stress, demonstrating potential as a plant-based therapeutic agent for metabolic and cardiovascular protection.

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Cite This Study

Essa et al. (2026) studied this question.

synapsesocial.com/papers/6974602bbb9d90c67120a024https://doi.org/10.1371/journal.pone.0339641
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