What question did this study set out to answer?

To investigate the relationship between histological outcomes and transcriptomic profiles in ulcerative colitis patients treated with filgotinib.

January 24, 20260 citations

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Association between endo-histological outcomes and colonic mucosal transcriptomic profiles in patients with ulcerative colitis receiving filgotinib.

FMFernando Magro GRGerhard Rogler BFBrian G Feagan

Puntos clave

To investigate the relationship between histological outcomes and transcriptomic profiles in ulcerative colitis patients treated with filgotinib.
Examined endo-histological outcomes in patients with ulcerative colitis
Measured gene expression changes
Analyzed pathways related to mucosal function
Filgotinib improved endo-histological outcomes in a dose-dependent manner
Gene expression alterations indicate restoration of mucosal homeostasis
Enhanced pathways were identified as correlating with clinical improvements

Resumen

Filgotinib improved endo-histological outcomes in patients with UC, with a dose-dependent effect on transcription. Gene expression changes and enriched pathways suggest that achieving endoscopic and histological endpoints in patients receiving FIL was associated with the restoration of mucosal homeostasis.

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Cite This Study

Magro et al. (Thu,) studied this question.

synapsesocial.com/papers/6974602bbb9d90c67120a195 https://doi.org/https://doi.org/10.1093/ecco-jcc/jjaf228

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