Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 24, 2026Journal of Applied Microbiology

Screening of Human and Environmental Microbiota-Derived Extracts Reveals Pathogen-Specific Anti-Virulence Activity

View Full Paper
Ask AI
Bookmark
Share

Authors

HSHana M. SawanRLRuth G. LedderAMAndrew J. McBain

Discussion

Loading...

Member takes

Overview

Screening of microbiome factors reveals pathogen-specific anti-virulence effects on bacteria, suggesting new treatment avenues.

Key Points

  • The aim was to identify microbiota-derived factors that suppress virulence traits in pathogenic bacteria.
  • Screened 82 cell-free extracts from human and soil bacterial isolates
  • Evaluated effects on planktonic growth, biofilm formation, and virulence using a Galleria mellonella model
  • Used a violacein-based assay to test quorum-sensing inhibition
  • 79% of extracts inhibited biofilm formation in P. aeruginosa
  • 24% impacted S. aureus biofilms
  • 57% increased mortality in E. coli-infected larvae
  • Extracts improved larval survival against P. aeruginosa infections
  • Proteomic analysis revealed modulation of biofilm regulation proteins

Cite This Study

Sawan et al. (2026) studied this question.

synapsesocial.com/papers/697460e9bb9d90c67120abbbhttps://doi.org/10.1093/jambio/lxaf299
View Full Paper
Ask AI
Bookmark
Share