PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
January 24, 2026Bone & Joint Open1 citationsOpen Access

Total hip arthroplasty restores population health-related quality of life norms

View Full Paper
AAAndrew D. AblettLYLiam Z. YappMCMr Nick Clement

Key Points

  • This research aims to evaluate health-related quality of life in patients undergoing total hip arthroplasty compared to a general population cohort.
  • Retrospective analysis using Edinburgh Arthroplasty database and Health Survey for England data.
  • Propensity score matching based on age, sex, and body mass index.
  • Primary outcome measured using the EQ-5D-3L index score; secondary outcomes included EQ-VAS and mediation analysis.
  • THA patients had significantly lower preoperative EQ-5D-3L scores compared to the matched general population.
  • At one-year follow-up, THA patients exceeded population norms for quality of life measures.
  • Patients over 85 showed the most significant improvement, matching their age peers' scores.
  • Mediation analysis indicated BMI's indirect effects on postoperative quality of life improvements through preoperative scores.

Abstract

Aims This study compares health-related quality of life (HRQoL) between patients undergoing primary total hip arthroplasty (THA) for osteoarthritis (OA) and a propensity-matched general population cohort. We also aimed to clarify the relationship between BMI and postoperative improvements, mediated via preoperative HRQoL. Methods In this retrospective study using the Edinburgh Arthroplasty database (1 January 2013 to 31 December 2022; n = 3,495) and Health Survey for England data (2010 to 2012; n = 25,320), propensity score matching (1:1) was performed based on age, sex, and BMI. The primary outcome was EuroQol five-dimension three-level questionnaire (EQ-5D-3L) index score. Secondary outcomes included EuroQol-visual analogue scale (EQ-VAS) and mediation analysis examining how preoperative EQ-5D-3L mediated the relationship between BMI and postoperative improvement. Results Preoperatively, THA patients had significantly lower EQ-5D-3L scores compared with matched general population (median difference: 0.280, bootstrapped 95% CIs; 0.258 to 0.306; p 85 years showed the greatest magnitude of improvements, restoring EQ-5D-3L scores equivalent with their age-matched general population peers (preoperative: 0.189 vs postoperative: 0.796, general population: 0.696). Mediation analysis revealed that BMI’s negative direct effect on improvements in EQ-5D-3L was counterbalanced by stronger indirect effects transmitted through preoperative scores (indirect effects: obesity I (30 to 34.9 kg/m 2 ): β = 0.038, p 85 years had the greatest magnitude of restoration. Postoperative HRQoL improvement was predominantly influenced by preoperative functional status, rather than BMI alone. These findings challenge current BMI-based eligibility thresholds and support surgical prioritization based on functional impairment severity. Cite this article: Bone Jt Open 2026;7(1):90–101.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Ablett et al. (2026) studied this question.

synapsesocial.com/papers/6974610cbb9d90c67120ae66https://doi.org/10.1302/2633-1462.71.bjo-2025-0226.r1
Ask AI
Helpful
Bookmark
Share
View Full Paper

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impressive Short-Term Improvement in Functional Outcome and Quality of Life after Primary Total Hip Arthroplasty (THA) in the Orthogeriatric Patient in a Prospective Monocentric Trial2024 · 6 citations
  2. 2Strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies2007 · 10,673 citations
  3. 3Optimal caliper widths for propensity‐score matching when estimating differences in means and differences in proportions in observational studies2010 · 4,030 citations
  4. 4Statistical Analysis with Missing Data, Third Edition2019 · 2,028 citations
  5. 5How Many Imputations are Really Needed? Some Practical Clarifications of Multiple Imputation Theory2007 · 2,859 citations