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January 9, 2026

Comprehensive Analysis to Reveal Nitrogen Metabolism-Associated Genes as a Prognostic Index in Head and Neck Squamous Cell Cancer.

Yiming Shen Wenfang Sun Chunfu Dai

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Key Points

To analyze nitrogen metabolism-related genes as potential biomarkers for prognosis in head and neck squamous cell carcinoma (HNSCC).
Established a gene signature related to nitrogen metabolism.
Analyzed the relationship between gene signature and immune microenvironment.
Evaluated drug sensitivity linked to the gene signature.
Identified a significant correlation between nitrogen metabolism genes and immune microenvironment.
Proposed potential biomarkers for prognosis and therapeutic targets in HNSCC.

Implication

Comprehensive analysis identifies nitrogen metabolism genes as prognostic indicators in HNSCC, suggesting new treatment insights.

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Cite This Study

Shen et al. (2026) studied this question.

synapsesocial.com/papers/69746149bb9d90c67120b1a3 https://doi.org/10.2174/0109298673427009251022060122

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1A Metabolic Gene Signature to Predict Overall Survival in Head and Neck Squamous Cell CarcinomaPrognostic Study · 2020 · 18 citations
2NAD+ Metabolism-Related Gene Profile Can Be a Relevant Source of Squamous Cell Carcinoma BiomarkersOriginal Research · 2024
3Metabolism-associated molecular classification and prognosis signature of head and neck squamous cell carcinoma2024 · 2 citations
4An integrated immune-related signature reveals prognostic and immune–microbiome–genomic interactions in head and neck squamous cell carcinomaCross-Sectional Study · 2026
5Role of mitophagy in head and neck squamous cell carcinoma: prognosis and immune insights2024

Identifying Biomarkers and Therapeutic Targets by Multiomic Analysis for HNSCC: Precision Medicine and Healthcare Management2024
Comprehensive Bioinformatic Analysis for Identification of Crucial Genes and Signaling Transduction Pathways in Head and Neck Squamous Cell Carcinoma2024
Deciphering a Prognostic Signature Based on Soluble Mediators Defines the Immune Landscape and Predicts Prognosis in HNSCC2024

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