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Synapse
January 24, 20265 citations

Histamine N-methyltransferase upregulation, cardiac hypertrophy, and heart failure.

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JZJinyan ZhangJWJia WangLLLiwei Liu

Key Points

  • The study investigates how HNMT contributes to cardiac hypertrophy and heart failure, and explores treatment options.
  • Analyzed the effects of HNMT on pathological hypertrophy in a cardiac model.
  • Examined the role of the SAM/FZD2/CaMKII signaling axis.
  • Evaluated the therapeutic potential of amodiaquine, an HNMT inhibitor.
  • Identified urinary N-methylhistamine as a potential heart failure biomarker.
  • HNMT upregulation was linked to increased cardiac hypertrophy and heart failure severity.
  • Amodiaquine showed promise in reversing heart failure effects.
  • Urinary N-methylhistamine was identified as a non-invasive biomarker for heart failure.

Abstract

HNMT exacerbates pathological hypertrophy and HF through SAM/FZD2/CaMKII axis. Amodiaquine, the inhibitor of HNMT, shows therapeutic potential against HF. Urinary N-methylhistamine emerges as a non-invasive HF biomarker.

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Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69746149bb9d90c67120b250https://doi.org/10.1093/eurheartj/ehaf1065
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