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Analysis reveals high prevalence of EGFR mutations in individuals from the Southeastern United States, suggesting need for testing.
Our analysis represents the largest study to date assessing the prevalence of germline EGFR mutations from both patients with lung cancer and unselected cohorts of individuals and presents evidence for increased prevalence of EGFR T790M mutations within the Southeastern United States. Given the high prevalence and documented hereditary risk of germline EGFR mutations, future studies investigating the role of familial testing and screening in these individuals is warranted.
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O'Brien et al. (2026) studied this question.
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