What question did this study set out to answer?

The aim is to examine the connection between HPA axis activity and menstrual irregularities in women with PCOS.

January 24, 2026

Relationship between hypothalamic-pituitary-adrenal axis activity and menstrual irregularities in women with polycystic ovary syndrome.

AZAli ZeynettinIzmir University OBOrhan BalikciIzmir University İDİsmail DemirIzmir University

Key Points

The aim is to examine the connection between HPA axis activity and menstrual irregularities in women with PCOS.
Assessment of menstrual patterns in women diagnosed with PCOS.
Analysis of metabolic and inflammatory markers.
Evaluation of perceived stress using the PSS-10 scale.
Menstrual irregularities correlate more with metabolic and inflammatory markers than with perceived stress.
PSS-10 score does not independently predict menstrual irregularities after adjustment.

Abstract

In PCOS, menstrual irregularity aligns more closely with metabolic and inflammatory markers than with perceived stress itself; after adjustment, PSS-10 score is not an independent predictor.

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