What question did this study set out to answer?

To explore the overlapping molecular mechanisms and biomarkers between systemic lupus erythematosus and type 2 diabetes mellitus.

January 24, 2026PLoS ONEOpen Access

The shared biomarkers and molecular mechanisms of systemic lupus erythematosus and type 2 diabetes

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Identifies shared biomarkers and molecular pathways in systemic lupus erythematosus and type 2 diabetes, suggesting new diagnostic strategies.

To explore the overlapping molecular mechanisms and biomarkers between systemic lupus erythematosus and type 2 diabetes mellitus.
Integrated bioinformatics analysis of gene expression data from public datasets
Identification of differentially expressed genes and co-expression modules
Functional enrichment and protein-protein interaction network analysis
Development of diagnostic gene panels using machine learning techniques
Validation using receiver operating characteristic analysis
Identified 551 shared differentially expressed genes between SLE and T2DM
Key genes enriched in type I interferon signaling and other inflammatory pathways
10-gene interferon-related hub showed strong discriminative performance in both conditions
A three-gene model exhibited potential utility with AUC values up to 1.00 in discovery and 0.928 in validation

Yang et al. (2026) studied this question.

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Identifies shared biomarkers and molecular pathways in systemic lupus erythematosus and type 2 diabetes, suggesting new diagnostic strategies.