What question did this study set out to answer?

The aim is to explore how nucleolus precursor bodies in human zygote pronuclei relate to embryo development potential.

January 25, 2026Reproduction0 citations

Nucleolus precursor bodies (NPBs) in human zygote pronuclei—still in the haze?

JFJ. FulkaCzech Academy of Sciences PLPasqualino LoiUniversity of Teramo JFJosef FulkaAnimal Science Research Institute

Key Points

The aim is to explore how nucleolus precursor bodies in human zygote pronuclei relate to embryo development potential.
Observation of nucleolus precursor bodies in one-cell stage human embryos.
Analysis of NPBs movement speed in pronuclei.
Comparison of development outcomes based on NPB characteristics.
Higher NPB movement speed correlates with better embryo development potential.
Distribution and number of NPBs may indicate chromosomal status (euploidy vs. aneuploidy).
The mechanisms linking NPBs and embryo quality remain unclear.

Abstract

Abstract The pronuclei in human one-cell stage embryos (zygotes) contain several nucleoli called nucleolus precursor bodies (NPBs). Based on their number and distribution, it is possible to predict the developmental potential of the zygote. Recently, it has been demonstrated that the speed of NPBs movement in pronuclei (PNs) may also indicate how the embryo will develop, as well as its chromosomal constitution (euploidy versus aneuploidy). These observations, however, do not elucidate the mechanisms behind these processes, and a deeper understanding will certainly be important for the more efficient production of healthy human embryos.

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