SPIB suppresses protective autophagy via the IFIT2/PINK1/Parkin axis to promote anoikis in colorectal cancer

Key Points

• The research aims to understand how SPIB influences autophagy and anoikis in colorectal cancer (CRC).
• Analyzed the effects of SPIB on CRC invasion and metastasis.
• Investigated the IFIT2/PINK1/Parkin signaling pathway.
• Evaluated the role of SPIB in regulating autophagy during cancer progression.
• SPIB was found to suppress protective autophagy in CRC cells.
• The IFIT2/PINK1/Parkin axis was identified as a key mechanism in SPIB's tumor-suppressive effects.
• SPIB influenced anoikis resistance, highlighting its potential as a therapeutic target.