Why Chloride Becomes Catastrophic - Taurine Buffer Failure and Glycocalyx Thinning, Lantern of Sulfur, Concept B, v 2026.12

This preprint introduces a portable mechanistic unit inside Lantern of Sulfur (LoS) Unified Version, v12 series / Concept B (Mechanistic Architecture): the Chloride–Taurine–Glycocalyx Triad. Rather than treating chloride as a background electrolyte, taurine as an optional supplement, and the endothelial glycocalyx as a niche vascular topic, the triad integrates them into a single threshold mechanism. The central claim is simple and testable: when chloride transport/load rises while taurine buffering capacity falls, glycocalyx integrity thins—amplifying RAAS misinterpretation and destabilizing fluid distribution. This produces a recognizable pattern signature: CO₂ (bicarbonate) sacrifice, paradoxical thirst with retention, autonomic/vascular clamp behavior, and rapid state shifts that are often misclassified as noncompliance or “anxiety.” The document is not a treatment protocol. It is a mechanistic scaffold with predictions and probe logic designed to be cited across multiple trigger contexts (dietary chloride overload, IV fluid sensitivity, diuresis cycles, dehydration spirals, endocrine-vascular fragility) without re-deriving the same causal frame each time. ↑chloride + ↓taurine → glycocalyx thinning → RAAS clampSee alsoDirectional Pressure Failure - When the Body Routes Pressure Into the Wrong Compartment, Lantern of Sulfur, Concept A, v2026.11, DOI: 10.5281/zenodo.18356815“In LoS geometry, triad failure commonly expresses as Directional Pressure Failure (DPF)—a compartment-routing inversion where RAAS and barrier behavior push pressure and fluid into the wrong places.”