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Observational study finds influence of ERAP1 and ERAP2 on susceptibility in birdshot chorioretinitis, suggesting potential pathways for intervention.
Our findings support a model in which ERAP1 and ERAP2 contribute to BSCR susceptibility, but have limited influence on disease severity. The observed pattern of reduced ERAP1 and elevated ERAP2 activity in BSCR patients may affect peptide processing and HLA-A29-mediated presentation.
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Loeliger et al. (2026) studied this question.
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