Combining Serum Pharmacochemistry and Metabolomics to Characterize the Synergistic Compatibility Principle of Polygonati Rhizoma and Angelicae Sinensis Radix for MAFLD Mitigation.

Key Points

• The aim is to explore how the combination of two herbs impacts MAFLD mitigation by identifying their synergistic effects.
• Utilized serum pharmacochemistry and metabolomics to analyze herbal components.
• Investigated targets and pathways related to MAFLD.
• Evaluated the synergistic effects of Polygonati Rhizoma and Angelicae Sinensis Radix.
• Identified multiple components and targets associated with the combined herbal treatment.
• Demonstrated potential mechanisms of synergism that may contribute to MAFLD mitigation.
• Found that JHP had broader effects compared to either herb alone.