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This review aims to explore the mechanisms linking sickle cell disease to male infertility and potential strategies for fertility preservation.

January 25, 2026LifeOpen Access

Sickle Cell Disease and Male Infertility: Pathophysiological Mechanisms, Clinical Manifestations, and Fertility Preservation Strategies—A Narrative Review

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This review aims to explore the mechanisms linking sickle cell disease to male infertility and potential strategies for fertility preservation.
Reviewed literature from PubMed, Cochrane Library, and Medscape until December 2025.
Focused on human studies related to male reproductive health in sickle cell disease.
Examined mechanistic pathways affecting semen quality and endocrine changes.
Identified mechanisms like vaso-occlusion, oxidative stress, and inflammation impacting male fertility.
Noted common conditions including oligozoospermia, azoospermia, and hypogonadism in affected males.
Highlighted the importance of early fertility discussions and options like semen cryopreservation.

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Narrative review summarizes mechanisms and fertility options for men with sickle cell disease, indicating clinical importance.

Roidos et al. (2026) studied this question.

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