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January 25, 20262 citations

Iron-Rim Lesions in the Optic Chiasm in Multiple Sclerosis: A Neuropathologic Case Series.

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ALAndrew LockhartMPMarco PisaHDHal Drakesmith

Key Points

  • To investigate the occurrence of iron-rim lesions in the anterior visual pathway of multiple sclerosis patients.
  • Investigated mixed active/inactive MS lesions
  • Utilized neuropathologic case series methodology
  • Assessed the relationship between iron-rim lesions and paramagnetic rim lesions
  • Iron-rim lesions were identified as common in the anterior visual pathway
  • Number of paramagnetic rim lesions correlates with disability extent
  • Challenges in detection of these lesions highlight the need for further research to address chronic inflammation

Abstract

IRLs are common in mixed active/inactive MS lesions in the anterior visual pathway. IRLs are the pathologic correlate of paramagnetic rim lesions (PRLs) on MRI, the number of which in the brain correlates with the extent of disability. PRLs have, heretofore, not been described in the anterior visual pathway. Future work aimed at overcoming the challenges in detecting these lesions in the anterior visual pathway is warranted, to ensure that extent of chronic inflammation is not underestimated.

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Cite This Study

Lockhart et al. (2026) studied this question.

synapsesocial.com/papers/6975b229feba4585c2d6db31https://doi.org/10.1212/wnl.0000000000214515
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