Abstract: The oral route is thought to have the highest patient compliance among the several administration modes. The gastrointestinal tract's sensitivity to environmental changes is the primary issue associated with oral delivery. If the drug is poorly water soluble and fails to penetrate cellular membranes, its bioavailability may be further diminished. A drugphospholipid complex method, which works similarly to the gastrointestinal tract's absorption of food components, could be used to overcome this obstacle. Drug-phospholipid complexes are excellent for oral administration because they are nontoxic and biodegradable. As a result, they are used as emulsifiers, matrix-forming excipients, and solubilizers in medications with limited solubility and permeability. Phospholipids have two different characteristics: high biocompatibility and outstanding amphiphilicity. Phospholipids have a wide range of applications in drug delivery systems, and their specific properties make them ideal to be utilized as important pharmacological excipients. The purpose of this research is to offer a thorough understanding of phospholipids, drug-phospholipid complex-building processes, phospholipids themselves, the mechanism by which they boost drug bioavailability, and some of the formulations' uses in drug delivery systems. Along with highlighting the links between phospholipid properties and applications, it will also explain how different phospholipid species influence medication delivery. The growing volume of current research on the strategy's use to boost drug oral bioavailability demonstrates its importance for effective oral administration.
Rathor et al. (Mon,) studied this question.