This review synthesizes evidence on pathophysiology and management in individuals with central compartment atopic disease, suggesting improved treatment strategies.
Central compartment atopic disease is a recently delineated inflammatory endotype of chronic rhinosinusitis. It is characterized by involvement of the central intranasal compartment—the middle turbinate, superior turbinate, and posterior superior nasal septum—and is associated with a predominantly polypoid phenotype. This review synthesizes current evidence on local allergic pathophysiology, diagnostic frameworks, and stratified management of central compartment atopic disease to facilitate accurate diagnosis and individualized treatment.
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Huang et al. (2026) studied this question.
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