Paternal preconception exercise and sperm epigenetic mechanisms: a systematic review on offspring health

January 23, 2026Epigenomics

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Key Points

To examine how paternal exercise before conception affects the epigenetic mechanisms in sperm and subsequent offspring health.
Conducted a systematic review of existing literature.
Evaluated studies on paternal exercise and its effects on sperm epigenetics.
Analyzed relationships between paternal health behaviors and offspring outcomes.
Paternal exercise positively influences sperm quality and genetic programming.
Healthier sperm was linked to better health outcomes for offspring.
Epigenetic changes in sperm were correlated with improved offspring development.

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Systematic review explores how paternal exercise influences offspring health through sperm mechanisms, indicating potential health benefits.

https://www.crd.york.ac.uk/prospero identifier is CRD420251141579.

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Rodrigues et al. (2026) studied this question.

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