Decoding the neural basis of olfactory dysfunction: a multimodal MRI study in CRS-OD.

C Zhang; Q Wang; Changyu Jiang; Z Tian; J Sha; X Wang; W Zhou; T Cui; Y Zang; Keman Xu

doi:10.4193/rhin25.096

January 23, 2026

Decoding the neural basis of olfactory dysfunction: a multimodal MRI study in CRS-OD.

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Key Points

The study aims to explore the neural underpinnings of olfactory dysfunction in chronic rhinosinusitis (CRS).
Utilized multimodal MRI techniques
Assessed olfactory bulb (OB) and gray matter changes
Examined functional connectivity patterns
Identified atrophy in olfactory bulbs
Observed gray matter atrophy in related regions
Found disrupted functional connectivity reflecting neural alterations

Implication

Multimodal MRI reveals neural alterations related to olfactory dysfunction in chronic rhinosinusitis, suggesting new insights into pathophysiology.

Abstract

CRS-OD is characterized by OB atrophy, gray matter atrophy, and disrupted FC, reflecting both peripheral and central neural alterations. Multimodal MRI may provide new insights into CRS-OD pathophysiology, warranting further longitudinal studies.

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Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6975b28afeba4585c2d6e089 https://doi.org/10.4193/rhin25.096

View at Publisher

Ask AI

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Decoding the neural basis of olfactory dysfunction: a multimodal MRI study in CRS-OD.

Key Points

Implication

Abstract

Discussion

Cite This Study

Decoding the neural basis of olfactory dysfunction: a multimodal MRI study in CRS-OD.

Key Points

Implication

Abstract

Discussion

Cite This Study

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