Impact of Protein Corona on Magnetic Particle Spectroscopy-Based Bioassays

Gabrielle Rose Moss; Christian Knopke; Solomon Diamond

doi:10.1039/d5na01037c

January 1, 2026Nanoscale AdvancesOpen Access

Impact of Protein Corona on Magnetic Particle Spectroscopy-Based Bioassays

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Key Points

The research aims to explore how protein corona influences the behavior of functionalized magnetic nanoparticles in bioassays.
Utilized magnetic nanoparticles and functionalized them with specific ligands.
Examined the aggregation of these nanoparticles in the presence of targeted biomolecules.
Performed assays to evaluate the impact of protein corona on bioassay outcomes.
Detected changes in the aggregation behavior of functionalized magnetic nanoparticles with varying protein concentrations.
Observed differences in assay sensitivity and specificity due to protein interactions.
Found that protein corona can lead to significant variations in bioassay results.

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Implication

Investigates how protein corona affects bioassays using magnetic nanoparticles, suggesting implications for assay accuracy.

Abstract

Magnetic nanoparticles (MNPs) can be functionalized with targeting ligands to give them an affinity for a biomolecule of interest. Functionalized MNPs (fMNPs) can aggregate in the presence of a multivalent...

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Cite This Study

Moss et al. (2026) studied this question.

synapsesocial.com/papers/6975b28afeba4585c2d6e158 https://doi.org/10.1039/d5na01037c

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Impact of Protein Corona on Magnetic Particle Spectroscopy-Based Bioassays

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Impact of Protein Corona on Magnetic Particle Spectroscopy-Based Bioassays

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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