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January 25, 2026JAMA Network OpenOpen Access

Appendectomy and Risk of Nonyphoidal Salmonella Infection in Children

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Authors

JGJyun-Yi GuoTaichung Veterans General HospitalLWLin WyTaichung Veterans General HospitalCLChing-Heng LinTaichung Veterans General Hospital

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Implication

Cohort study reports increased risk of NTS infection in children post-appendectomy, indicating need for preventive strategies.

Key Points

  • To investigate the association between pediatric appendectomy and the subsequent risk of nontyphoidal Salmonella infection.
  • Nationwide population-based cohort study using data from Taiwan’s National Health Insurance Research Database.
  • Children who underwent appendectomy were matched 1:4 to controls based on age, sex, and index date.
  • Cox proportional hazards models were used to estimate adjusted hazard ratios for infection risk.
  • The appendectomy group had a higher risk of NTS infection (aHR, 1.58; 95% CI, 1.17-2.13).
  • Children under 5 years showed an even higher risk (aHR, 2.00; 95% CI, 1.35-2.97).
  • The risk remained elevated in follow-up periods but was not statistically significant for 1 to 4 years (aHR, 1.51) and 5 or more years (aHR, 1.78).

Cite This Study

Guo et al. (2026) studied this question.

synapsesocial.com/papers/6975b2aefeba4585c2d6e1f7https://doi.org/10.1001/jamanetworkopen.2025.55278
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Also Consider

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