What question did this study set out to answer?

Evaluate the involvement of mt-cyb gene mutations in breast cancer progression among Chadian women.

Implication of iMt-CYB/i Gene Mutations in the Genetic Evolution of Breast Cancer in Chad

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Evaluates mt-cyb gene mutations' role in breast cancer progression in Chadian women, suggesting new pathways for understanding the disease.

Evaluate the involvement of mt-cyb gene mutations in breast cancer progression among Chadian women.
Analyzed mt-cyb gene variability in 43 patients using PCR-sequencing technique.
Processed sequencing data with Mutation Surveyor software to compare chromatograms with reference.
Identified mutations and assessed their potential pathogenicity.
Identified 53 mutations, with 39.62% being homozygous and 60.37% heterozygous.
69.81% of mutations were non-synonymous substitutions affecting amino acid sequences.
48.64% of mutations were potentially deleterious, while 51.35% classified as neutral polymorphisms.
67.56% of non-synonymous mutations were considered pathogenic.

Issa et al. (2026) studied this question.

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Evaluates mt-cyb gene mutations' role in breast cancer progression in Chadian women, suggesting new pathways for understanding the disease.