Our findings demonstrate that the two loci, rs10440635 and rs4133101 in PTGER4, were not found to be associated with susceptibility to AAU in this population. Specifically, for rs10440635, the odds ratio (OR) was 0.924 (95% CI: 0.757-1.128, p = 0.438), and for rs4133101, the OR was 0.918 (95% CI: 0.777-1.085, p = 0.314). Even after stratifying the analysis by HLA-B27 status, no statistically significant association was observed. To further elucidate the potential role of PTGER4 in these conditions, additional studies with larger sample sizes, broader genetic variants, and more diverse ethnic populations are warranted.contribution of PTGER4 to these diseases.
Wu et al. (Fri,) studied this question.