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January 25, 2026Human GenomicsOpen Access

Genetic contribution to severe COVID-19 in adults under 60 years without major comorbidities in the German National Pandemic Cohort Network (NAPKON)

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Authors

AAAyda AbolhassaniTAT. Madhusankha AlawathurageUniversity Hospital BonnASAxel SchmidtUniversity Hospital Bonn

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Overview

Genome-wide association study reveals genetic variants affecting severe COVID-19 in younger adults, suggesting new research directions.

Key Points

  • The research aims to identify rare genetic variants contributing to severe COVID-19 in young adults with no major health issues.
  • Genome sequencing of 110 hospitalized COVID-19 patients under 60 years old
  • Analysis of variants in IFN-I-IEI and GWAS-prioritized genes
  • Classification of variants based on ACMG criteria
  • Calculation of polygenic risk scores for further analysis
  • 7 variants of uncertain significance found in IFN-I-IEI genes
  • 13 candidate variants identified in GWAS risk genes
  • Higher polygenic risk scores in younger individuals (<40 years)
  • Lower polygenic risk scores in carriers of rare variants compared to non-carriers

Cite This Study

Abolhassani et al. (2026) studied this question.

synapsesocial.com/papers/6975b32bfeba4585c2d6ea1ehttps://doi.org/10.1186/s40246-025-00904-9
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Also Consider

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  4. 4The German National Pandemic Cohort Network (NAPKON): rationale, study design and baseline characteristics2022 · 64 citations
  5. 5Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity2021 · 42 citations