Key result
Chemotherapy, surgery, and radiation yield a partial response in seminal vesicle desmoplastic small round cell tumor.
Why the study?
Desmoplastic small round cell tumor is an aggressive, uncommon disease that is difficult to diagnose.
Multimodality treatment including chemotherapy, surgery, and radiation therapy can yield a good short-term response in rare cases of DSRCT of the seminal vesicle.
May support multimodality therapy in rare seminal vesicle DSRCT; hypothesis-generating and leaves optimal management open.
Desmoplastic small round cell tumor (DSRCT) is an aggressive, uncommon disease and difficult to diagnose and identified by translocation t(11;22) (p13;q12) leading to fusion transcript EWSR1–WT1 . A case of DSRCT of the seminal vesicle diagnosed by histopathology, immunohistochemistry, and genetic study, and treated with chemotherapy, surgery, and radiation therapy on the lines of Ewing Sarcoma protocol is presented. Four cycles of chemotherapy was given, and he had a partial response, so underwent debulking surgery followed by radiation therapy.
No takes yet. Share an insight, caveat, or question.
Rastogi et al. (2026) studied this question. Treatment of desmoplastic small round cell tumor in the seminal vesicle with chemotherapy, surgery, and radiation led to a partial response in the patient.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: