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January 25, 2026Journal of Translational Medicine2 citationsOpen Access

Senescence-induced endothelial-to-mesenchymal transition accelerates the subretinal fibrosis in neovascualr age-related macular degeneration

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YWYinhao WangHMHuiling MaJGJiayun Ge

Key Points

  • This study investigates how senescence in endothelial cells contributes to subretinal fibrosis in neovascular age-related macular degeneration.
  • Analyzed the effects of senescent endothelial cells on fibrosis
  • Examined the role of endothelial-to-mesenchymal transition (EndMT)
  • Assessed potential therapeutic strategies targeting senescent cells
  • Finding that senescent endothelial cells promote subretinal fibrosis
  • EndMT is identified as a key process in this acceleration
  • Suggests that targeting these cells could help prevent vision loss

Abstract

The accumulation of senescent endothelial cells promotes subretinal fibrosis via EndMT in nAMD. Targeting these cells represents a promising therapeutic strategy for mitigating fibrosis-associated vision loss.

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Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6975b4fd5a65d392b01e5c4fhttps://doi.org/10.1186/s12967-026-07707-z
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