Key result
Individual antidepressants vary significantly in their effects on cardiometabolic measures.
Why the study?
Current treatment guidelines for depression do not reflect clinically meaningful differences in individual antidepressants physiological effects, particularly on cardiometabolic measures.
Do individual antidepressants differ in their physiological and cardiometabolic effects?
Meta-Analysis
Do individual antidepressants differ in their physiological and cardiometabolic effects?
Individual antidepressants exhibit marked differences in physiological and cardiometabolic effects, which are not currently reflected in depression treatment guidelines.
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Clinicians should factor cardiometabolic profiles into antidepressant selection; challenges guidelines treating agents as interchangeable.
A systematic review and network meta‐analysis that included 151 studies has found marked differences in individual antidepressants' physiological effects, particularly on cardiometabolic measures. Current treatment guidelines for depression do not reflect these clinically meaningful differences, the investigators stated. Results of the network meta‐analysis were published online Oct. 21, 2025 in The Lancet .
A 2026 study conducted a meta-analysis in Depression. Antidepressants was evaluated on Physiological effects, particularly cardiometabolic measures. A network meta-analysis of 151 studies revealed marked differences in the physiological and cardiometabolic effects of individual antidepressants.
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