Randomized controlled trial shows melatonin does not reduce anxiety or PTSD in surgery patients, suggesting alternative approaches are needed.
A single 15 mg preoperative dose of sublingual melatonin did not demonstrate any significant benefit over placebo in reducing perioperative anxiety, improving psychomotor performance, enhancing postoperative sleep quality, or preventing early post-traumatic stress symptoms in patients undergoing mandibular third molar surgery.
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Rosa et al. (2020) studied this question.
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