Background Precision medicine is an emerging approach that tailors treatments based on an individual’s genetic profile. The UAE has made significant strides in this field through initiatives like the National Genomics Strategy and the Emirati Genome Program. However, public awareness and engagement remain key challenges. Purpose This study assesses awareness, acceptance, and utilization of precision medicine among UAE residents. Methods A cross-sectional online survey was conducted using a snowball sampling method. The survey collected demographic data, health status, knowledge, and experiences with precision medicine. Descriptive statistics and chi-square tests were used to analyze associations. Results Most participants (94.3%) were under 50 years old, 62.5% were female, and 60.0% held a bachelor’s degree. Awareness of precision medicine was moderate (55.3%), with higher familiarity among females and students. While 40% believed its main benefit was optimizing drug effectiveness, 38.5% viewed it as crucial for preventing adverse drug reactions. Family and friends (29.5%) were the primary sources of information, yet 25.5% had never heard of precision medicine. Awareness of insurance coverage was low, with 59.0% uncertain about their policy. Genetic testing participation was associated with education level (p
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