Reassessing prognostic markers in metastatic renal cell carcinoma in the era of immune checkpoint inhibitors: the enduring value of body composition, nutritional, and inflammatory indices.

N. Tsuchiya; Sei Naito; Hiroki Fukuhara; Hayato Nishida; Mayu Yagi; Yuki Takai; Atsushi Yamagishi; Takafumi Narisawa; Shinta Suenaga

doi:10.1007/s10147-025-02855-6

January 23, 2026

Reassessing prognostic markers in metastatic renal cell carcinoma in the era of immune checkpoint inhibitors: the enduring value of body composition, nutritional, and inflammatory indices.

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Key Points

To evaluate the importance of body composition, nutritional status, and inflammation in mRCC patients treated with immune checkpoint inhibitors.
Analyzed body composition and nutritional status indices in patients with metastatic renal cell carcinoma.
Assessed systemic inflammation markers as potential prognostic indicators.
Evaluated the efficacy of immune checkpoint inhibitor therapy in relation to these indices.
Indices reflecting body composition are associated with treatment outcomes in mRCC.
Nutritional and inflammatory indices provide additional prognostic value for patient management.
Continued relevance of these markers observed even in the context of novel immunotherapies.

Implication

Observational findings reveal valuable prognostic markers in metastatic renal cell carcinoma, suggesting ongoing relevance in treatment planning.

Abstract

Several indices reflecting body composition, nutritional status, and systemic inflammation remain valuable prognostic markers in patients with mRCC receiving ICI-based first-line therapy.

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Cite This Study

Tsuchiya et al. (2026) studied this question.

synapsesocial.com/papers/697703af722626c4468e8b4d https://doi.org/10.1007/s10147-025-02855-6

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Reassessing prognostic markers in metastatic renal cell carcinoma in the era of immune checkpoint inhibitors: the enduring value of body composition, nutritional, and inflammatory indices.

Key Points

Implication

Abstract

Discussion

Cite This Study

Reassessing prognostic markers in metastatic renal cell carcinoma in the era of immune checkpoint inhibitors: the enduring value of body composition, nutritional, and inflammatory indices.

Key Points

Implication

Abstract

Discussion

Cite This Study

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