Clinical outcomes of metastatic non-clear cell renal cell carcinoma: a real-world single-centre experience

Jian Wu; Chuan-Zhen Cao; Hong-Lei Cui; Man-Xiang Chen; Lina Gao; Shan Zheng; A. Zhou; Youyan Guan; Xingang Bi; H. C. Shi; Jianzhong Shou

doi:10.1080/07853890.2026.2613590

January 23, 2026Annals of MedicineOpen Access

Clinical outcomes of metastatic non-clear cell renal cell carcinoma: a real-world single-centre experience

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Key Points

The aim is to assess clinical outcomes and identify risk factors affecting prognosis in metastatic non-clear cell renal cell carcinoma (nccRCC).
Analyzed data from a single-center cohort of patients with metastatic nccRCC.
Identified independent risk factors such as unclassified RCC pathology and poor IMDC risk group.
Evaluated the efficacy of IO-TKI treatment in this population.
Patients with unclassified pathology and poor IMDC risk had worse prognoses.
IO-TKI treatment demonstrated promising efficacy in managing metastatic nccRCC.

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Implication

Real-world evidence shows poor prognosis in metastatic nccRCC, with IO-TKI indicating potential benefits.

Abstract

For metastatic nccRCC, unclassified RCC pathology and poor IMDC risk group were identified as independent risk factors for poor prognosis and IO-TKI showed promising efficacy in patients with metastatic nccRCC.

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Cite This Study

Wu et al. (2026) studied this question.

synapsesocial.com/papers/69770413722626c4468e920f https://doi.org/10.1080/07853890.2026.2613590

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Clinical outcomes of metastatic non-clear cell renal cell carcinoma: a real-world single-centre experience

Key Points

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Implication

Abstract

Discussion

Cite This Study

Clinical outcomes of metastatic non-clear cell renal cell carcinoma: a real-world single-centre experience

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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