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April 23, 2025American Journal of Psychiatry

Systemic Inflammation and Anhedonic Responses to an Inflammatory Challenge in Adults With Major Depressive Disorder: A Randomized Controlled Trial

Jonathan Savitz Leandra K. Figueroa‐Hall T. Kent Teague Hung‐Wen Yeh Haixia Zheng Rayus Kuplicki Kaiping Burrows Nour El-Sabbagh MacGregor Thomas Isaac Ewers Yoon‐Hee Cha Salvador Guinjoan Sahib S. Khalsa Martin P. Paulus Michael R. Irwin

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Abstract

Depressed individuals with systemic inflammation appeared to be biologically primed to respond more strongly to inflammatory stimuli, and psychologically, this sensitization impacted the symptom of anhedonia, the primary outcome.

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Savitz et al. (2025) studied this question.

synapsesocial.com/papers/6977fe5c76a395df3f7c7e21 https://doi.org/10.1176/appi.ajp.20240142

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