Key result
Bimodal edema after myocardial ischemia-reperfusion involves an initial reperfusion wave and a second healing wave.
The two waves of post-ischemia/reperfusion edema are driven by distinct mechanisms: reperfusion injury initially, followed by tissue healing processes.
May inform timing of anti-edema interventions post-MI; leaves open whether targeting distinct waves improves outcomes.
The 2 waves of the post-I/R edematous reaction are related to different pathophysiological phenomena. Although the first wave is secondary to reperfusion, the second wave occurs mainly because of tissue healing processes.
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Fernández‐Jiménez et al. (2015) studied this question. The bimodal edema phenomenon after myocardial ischemia/reperfusion consists of an initial wave due to reperfusion and a second wave related to tissue healing processes.
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