Diagnostic and Prognostic Significance of Circulating HPV cfDNA in Cervical Cancer: A Systematic Review and Meta-analysis

Key Points

• This research aims to evaluate the diagnostic and prognostic significance of circulating HPV cfDNA in cervical cancer.
• Conducted a systematic review of literature
• Performed a meta-analysis of existing studies
• Assessed the specificity and prognostic value of HPV cfDNA
• HPV cfDNA demonstrated high specificity for cervical cancer detection
• The prognostic value of HPV cfDNA was found to be strong
• Supports clinical utility in treatment surveillance