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Analysis reveals depressive symptoms mediate the impact of allostatic load on frailty progression, indicating importance for interventions.
Socioeconomic factors influenced frailty onset but not its progression, whereas depressive symptoms mediated approximately 17% of the effect of ALS on frailty development over time. These findings highlight the importance of exploring the effect of interventions for depression on frailty progression.
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Azizzadeh et al. (2026) studied this question.
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