Association of allostatic load with frailty trajectories and the mediating role of depressive symptoms

Key Points

• The study aims to investigate how allostatic load relates to frailty trajectories and the role of depressive symptoms.
• Examined the association between allostatic load and frailty.
• Analyzed the mediating role of depressive symptoms.
• Considered socioeconomic factors influencing frailty onset and progression.
• Socioeconomic factors influenced the onset of frailty but not its progression.
• Depressive symptoms mediated approximately 17% of the effect of allostatic load on frailty development.