Systematic review reports cognitive training does not alter brain structure in non-demented individuals, suggesting caution in its preventive efficacy.
Training groups showed no significant morphological or microstructural modifications compared to control conditions. The current results of objective markers are not powerful enough to recommend cognitive training as a preventive method. Future research should focus on proper randomization, elimination of baseline differences and use standardized techniques. The review was pre-registered with PROSPERO (ID: CRD42023485440).
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Radics et al. (2026) studied this question.
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