Key result
Genetically predicted 50 mg/dL higher Lp(a) linked to ~5% greater ischemic stroke risk.
Why the study?
Does a genetically predicted increase in Lp(a) levels increase the risk of cerebrovascular disease outcomes?
Population
Individuals with genetic data for Lp levels, ischemic stroke subtypes, intracranial hemorrhage subtypes, and…
Comparison
Genetically predicted 50 mg/dL increase in Lp… vs Lower genetically predicted Lp(a) levels
Design
Other, Mendelian randomization
Authors
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Genetically predicted higher Lp(a) levels are strongly associated with ischemic stroke due to large artery atherosclerosis, supporting the targeting of Lp(a) in atherosclerotic stroke prevention.
Observational (n=343,681)
Does a genetically predicted increase in Lp(a) levels increase the risk of cerebrovascular disease outcomes?
Odds Ratio: 1.05 (95% CI 1.03–1.08)
p-value: p=2.05x10 -4
Genetically predicted higher Lp(a) levels are strongly associated with ischemic stroke due to large artery atherosclerosis, supporting the targeting of Lp(a) in atherosclerotic stroke prevention.
Daghlas et al. (2026) conducted an observational in Cerebrovascular disease (n=343,681). Genetically predicted Lipoprotein(a) levels was evaluated on All-cause ischemic stroke (OR 1.05, 95% CI 1.03-1.08, p=2.05x10 -4). A genetically predicted 50 mg/dL increase in Lipoprotein(a) levels was significantly associated with an increased risk of all-cause ischemic stroke (OR 1.05; 95% CI 1.03-1.08; P=2.05x10 -4).
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