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February 2, 2026Annals of Medicine0 citationsOpen Access

A system-level metastable model of cancer evolution: integrating replication stress, cell cycle deregulation and chromosomal instability

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DMDi MaJWJ WangYCYicong Chen

Key Points

  • This review aims to explore the interconnected roles of replication stress, cell cycle deregulation, and chromosomal instability in cancer evolution.
  • Integrated analysis of the RS-CCD-CIN axis in cancer biology.
  • Review of existing literature on cancer evolution mechanisms.
  • Discussion of implications for therapeutic strategies.
  • Revealed the fragility of the RS-CCD-CIN axis as a model for cancer evolution.
  • Identified how this interconnected framework could collapse under certain conditions.

Abstract

This review highlights the RS-CCD-CIN axis as a fragile and metastable architecture that supports cancer evolution, while also being susceptible to collapse. A deeper understanding of this interconnected framework may inform the development of therapeutic strategies and enhance the management of resistance.

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Cite This Study

Ma et al. (2026) studied this question.

synapsesocial.com/papers/6980fc37c1c9540dea80e0aehttps://doi.org/10.1080/07853890.2026.2620184
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