The study reveals lactate exacerbates renal damage through H3K18 lactylation in acute kidney injury, suggesting new treatment targets.
The present study unveils a previously unidentified epigenetic pathway in AKI, whereby lactate-driven H3K18 lactylation transcriptionally activates HSPA6, consequently promoting cuproptosis and exacerbating renal damage. The "lactate-H3K18la-HSPA6" axis has been identified as a promising new target for therapeutic intervention in AKI.
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Sui et al. (2026) studied this question.
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